← All NFL picks for Thursday, September 17, 2026

Detroit Lions vs Buffalo Bills

Thursday, September 17, 2026 — NFL Prediction & Pick

Our model leans Buffalo Bills
moderate lean

The model leans Buffalo Bills based on the cumulative weight of small edges across multiple factors.

Matchup Breakdown

Detailed factor breakdown is not available for this game yet.

Betting Lines

Buffalo Bills -5.5 (LowVig.ag) | O/U 54.5 (Matchbook)

Final Score

Detroit Lions 31, Buffalo Bills 41 — Buffalo Bills win — Model pick was correct

This analysis is generated by a statistical model and is intended for informational and entertainment purposes only. It does not constitute financial or betting advice. Past model performance does not guarantee future results. Please gamble responsibly.