← All NFL picks for Sunday, December 14, 2025

Tennessee Titans vs San Francisco 49ers

Sunday, December 14, 2025 — NFL Prediction & Pick

Our model leans San Francisco 49ers
strong lean

The model leans San Francisco 49ers primarily because of advantages in Market line and Form. The projected margin is SF by 11.8 points. That lean is driven mainly by market line and form.

On balance, more tracked inputs leaned San Francisco 49ers (2 edges vs 0 for Tennessee Titans).

The model's lean lines up with that edge count. The score model and the raw stat comparison point the same way.

Matchup Breakdown

Market line — leans San Francisco 49ers

Market line is a large contribution and supports SF by about 7.2 points of margin. The market spread feature is -12.5.

Form — leans San Francisco 49ers

Form is a large contribution and supports SF by about 0.9 points of margin. Points scored per game: SF 25.0, TEN 17.0.

Betting Lines

San Francisco 49ers -12.5 (Matchbook) | O/U 44.5 (Matchbook)

Final Score

Tennessee Titans 24, San Francisco 49ers 37 — San Francisco 49ers win — Model pick was correct

This analysis is generated by a statistical model and is intended for informational and entertainment purposes only. It does not constitute financial or betting advice. Past model performance does not guarantee future results. Please gamble responsibly.