← All NFL picks for Sunday, September 28, 2025

Jacksonville Jaguars vs San Francisco 49ers

Sunday, September 28, 2025 — NFL Prediction & Pick

Our model leans San Francisco 49ers
moderate lean

The model leans San Francisco 49ers primarily because of advantages in Market line. The projected margin is SF by 2.2 points. That lean is driven mainly by market line. Context pulls the other way.

Tracked inputs were split fairly evenly between the two sides.

The model's lean lines up with that edge count. The score model and the raw stat comparison point the same way.

Matchup Breakdown

Market line — leans San Francisco 49ers

Market line is a large contribution and supports SF by about 1.3 points of margin. The market spread feature is -3.5.

Context — leans Jacksonville Jaguars

Context pulls the other way and favors JAX by about 0.5 points of margin.

Betting Lines

San Francisco 49ers -3.0 (Matchbook) | O/U 46.0 (Pinnacle)

Final Score

Jacksonville Jaguars 26, San Francisco 49ers 21 — Jacksonville Jaguars win — Model pick was incorrect

This analysis is generated by a statistical model and is intended for informational and entertainment purposes only. It does not constitute financial or betting advice. Past model performance does not guarantee future results. Please gamble responsibly.